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Plankton Research Group · Publications

Position papers, re-analyses,
methodological reports.

PRG-PAP-002 · Position paper

The Empirical Limit: When N=1 Meets the FDA

Personalised medicine promises treatments tailored to individual genetics. But this hyper-specificity creates a paradox: how do we prove efficacy when every patient is their own unique trial?

14 January 2025 · 12 pages

PRG-PAP-001-2026-05 · Position paper

The untapped market for recreational placebos

A market, effect and risk analysis. Cohen's d ≈ 0.10 between verum and placebo across 348 AACT depression studies; a 2.3-fold centre effect in the Indo-RCT as evidence of contextual action.

11 May 2026 · 13 pages

In preparation

  • · Re-analysis Indo-RCT: the study centre as an unobserved intervention
  • · Cross-domain comparison depression × pain in the AACT extract
  • · Methodological report: aggregate data vs. patient-level data in placebo research